Journal article
Effect of Early Sustained Prophylactic Hypothermia on Neurologic Outcomes among Patients with Severe Traumatic Brain Injury
DJ Cooper, AD Nichol, M Bailey, S Bernard, PA Cameron, S Pili-Floury, A Forbes, D Gantner, AM Higgins, O Huet, J Kasza, L Murray, L Newby, JJ Presneill, S Rashford, JV Rosenfeld, M Stephenson, S Vallance, D Varma, SAR Webb Show all
JAMA Journal of the American Medical Association | AMER MEDICAL ASSOC | Published : 2018
Abstract
Importance After severe traumatic brain injury, induction of prophylactic hypothermia has been suggested to be neuroprotective and improve long-term neurologic outcomes. Objective To determine the effectiveness of early prophylactic hypothermia compared with normothermic management of patients after severe traumatic brain injury. Design, Setting, and Participants The Prophylactic Hypothermia Trial to Lessen Traumatic Brain Injury-Randomized Clinical Trial (POLAR-RCT) was a multicenter randomized trial in 6 countries that recruited 511 patients both out-of-hospital and in emergency departments after severe traumatic brain injury. The first patient was enrolled on December 5, 2010, and the las..
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Awarded by Health Research Board
Funding Acknowledgements
This trial was supported by grants from the National Health and Medical Research Council of Australia (545901 and 1121037); the Victorian Neurotrauma Initiative (VNI for the Transport Accident Commission, Victoria, Australia) (VNI D162); the Teaching Hospital of Besancon, France; and Health Research Board of Ireland Clinical Trial Network Program.